GLP-1 peptides can degrade if shipped or stored warm, which reduces effectiveness.
Compounded GLP-1s generally need refrigeration. Improper cold-chain handling during shipping can degrade the peptide. Ask whether shipping is refrigerated and included, and follow storage instructions on arrival.
| What to know |
|---|
| GLP-1 peptides can degrade if shipped or stored warm, which reduces effectiveness. |
| Compounded GLP-1s generally need refrigeration. |
The FDA resolved the tirzepatide (Dec 2024) and semaglutide (Feb 2025) shortages, and wind-down deadlines passed in 2025. On Apr 30, 2026 the FDA proposed excluding these drugs from the 503B bulks list; public comments are due by Jun 29, 2026. Patient-specific 503A compounding continues only narrowly, and cost alone is not a clinical need. Full regulatory status →
Compounded semaglutide and tirzepatide are not FDA-approved and are not the same as Wegovy, Ozempic, Zepbound, or Mounjaro. The FDA does not review compounded drugs for safety, effectiveness, or quality before marketing. Primary source: FDA — Human Drug Compounding.